Hydrazonoyl Halides as Precursors for Synthesis of Novel Bioactive Thiazole and Formazan Derivatives-Reference-Cited by-同舟云学术

Hydrazonoyl Halides as Precursors for Synthesis of Novel Bioactive Thiazole and Formazan Derivatives

Published:2012-11 Issue:11 Volume:36 Page:660-664
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Farghaly Thoraya A.¹,Abbas Eman M.H.²

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt

2. Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt

Abstract

A new series of substituted 4-methyl-5-(arylazo)-2-[ N‘-(6,7,8,9-tetrahydro-benzocyclohepten-5-ylidene)-hydrazino]-thiazoles and 5-(arylhydrazono)-2-[ N‘-(6,7,8,9-tetrahydro-benzocyclohepten-5-ylidene)-hydrazino]-thiazol-4-one were prepared by reaction of hydrazonoyl chlorides with a thiosemicarbazone derivative. The tautomeric structures of the products were studied using electronic absorption and NMR spectroscopy. The site-selectivities of the reactions of hydrazonoyl halides with benzocyclohepten-5-one hydrazone were also investigated. In addition, the antimicrobial activity of some of the products was evaluated. Many derivatives have promising activities against antibacterial and antifungal species.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751912X13491094428620

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