Affiliation:
1. Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt
2. Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Abstract
Background & Objective:
Six novel complexes of transition metal namely,
[CoLCl2(H2O)2]0.5H2O, [NiLCl2(H2O)2]0.5H2O, [CuLCl2]0.5H2O, [ZnLCl2], [PdLCl2]H2O and
[CdLCl2]H2O, where L is benzocycloheptenone thiosemicarbazone ligand, have been obtained. The
confirmation of the structures of the obtained metal chelates depends on the different spectral and
physicochemical techniques including CHN analysis, infrared spectra, molar conductivity measurement,
UV-vis, thermogravimetric analysis and magnetic moment. The infrared spectral results ascertained
that the ligand behaved as neutral bidentate connecting the metal centers via N and S atoms of
C=N and C=S groups, respectively.
Methods:
The UV-Vis, molar conductivity and magnetic susceptibility results implied that the geometrical
structures of the metal chelates are octahedral for Co(II) & Ni(II) complexes, tetrahedral for
Zn(II) & Cd(II) complexes and square planar for Cu(II) & Pd(II) complexes which have been confirmed
by molecular modeling studies.
Conclusion:
Moreover, the mode of interaction between some chosen metal complexes towards SSDNA
has been thoughtful by UV-Vis spectra and viscosity measurements. The value of the intrinsic
binding constant (Kb) for the examined compounds has been found to be lower than the binding affinity
of the classical intercalator ethedium bromide. Also, the viscosity measurements of the complexes
proved that they bind to DNA, most likely, by a non-intercalative mode like H-bonding or electrostatic
interactions.
Publisher
Bentham Science Publishers Ltd.
Subject
Drug Discovery,Pharmacology,General Medicine
Cited by
17 articles.
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