Catalyst-Free, One-Pot, Three-Component Synthesis of Pyrimido[4,5-b] Quinoline-4-Amines under Microwave Irradiation-Reference-Cited by-同舟云学术

Catalyst-Free, One-Pot, Three-Component Synthesis of Pyrimido[4,5-b] Quinoline-4-Amines under Microwave Irradiation

Published:2018-10 Issue:10 Volume:42 Page:525-528
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Xu Jiao¹²,Zhang Li Hong²,Liu Xiu Bo²,Ma Wei¹²,Ma Ling¹,Ma Yan³,Yang Jian Nan⁴,Wang Dao Lin⁴

Affiliation:

1. State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, Harbin 150040, P.R. China

2. Heilongjiang University of Chinese Medicine, Harbin 150040, P.R. China

3. Harbin University of Commerce, Harbin 150040, P.R. China

4. College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121003, P.R. China

Abstract

An efficient and facile one-pot, three-component protocol for the synthesis of pyrimido[4,5-b]quinoline-4-amines from the condensation of 2-aminoquinoline-3-carbonitrile, N,N-dimethylformamide dimethyl acetal and primary amines under microwave irradiation is reported. This efficient, straightforward procedure led to the desired products in high yields without the need for a catalyst or for a tandem addition–elimination–cyclisation reaction.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751918X15366615479040

Reference21 articles.

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2. Structure−Activity Relationships for a Series of Quinoline-Based Compounds Active against Replicating and Nonreplicating Mycobacterium tuberculosis

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4. Palladium(0)-catalyzed cyclopropane C–H bond functionalization: synthesis of quinoline and tetrahydroquinoline derivatives

5. A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

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