Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter (PfCRT)-Reference-Cited by-同舟云学术

Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter (PfCRT)

Published:2011-09-13 Issue:19 Volume:54 Page:6956-6968
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zishiri Vincent K.¹,Joshi Mukesh C.¹,Hunter Roger¹,Chibale Kelly¹²,Smith Peter J.³,Summers Robert L.⁴,Martin Rowena E.⁴,Egan Timothy J.¹

Affiliation:

1. Department of Chemistry, University of Cape Town, Private Bag, Rondebosch 7701, South Africa

2. Institute for Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

3. Division of Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa

4. Research School of Biology, The Australian National University, Canberra, ACT 0200, Australia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2009698

Reference30 articles.

1. Prospects for the treatment of drug-resistant malaria parasites

2. Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position

3. Chloroquine Transport via the Malaria Parasite’s Chloroquine Resistance Transporter

4. IN VITRO ANTIMALARIAL SUSCEPTIBILITY PROFILE AND PRCRT/PFMDR-1 GENOTYPES OF PLASMODIUM FALCIPARUM FIELD ISOLATES FROM MALAWI

5. Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi

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