Chloroquine Transport via the Malaria Parasite’s Chloroquine Resistance Transporter-Reference-Cited by-同舟云学术

Chloroquine Transport via the Malaria Parasite’s Chloroquine Resistance Transporter

Published:2009-09-25 Issue:5948 Volume:325 Page:1680-1682
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Martin Rowena E.¹,Marchetti Rosa V.¹,Cowan Anna I.²,Howitt Susan M.¹,Bröer Stefan¹,Kirk Kiaran¹

Affiliation:

1. Research School of Biology, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

2. The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

Abstract

Malaria Chloroquine Resistance Transporter Malaria is one of the most deadly infectious diseases in the world today, and the emergence and spread of chloroquine-resistant parasites has been a disaster for world health. The Chloroquine Resistance Transporter (PfCRT) was originally identified because mutations in this protein confer chloroquine resistance in the human malaria parasite, Plasmodium falciparum . However, the mechanism by which they do so has been the subject of ongoing debate. Martin et al. (p. 1680 ) have now succeeded in expressing PfCRT at the surface of Xenopus laevis oocytes, establishing a robust and reproducible heterologous system for the study of this protein. The resistance-conferring form of the protein mediates the transport of chloroquine, whereas wild-type PfCRT does not. Thus, as suspected, chloroquine resistance in the malaria parasite indeed arises as a result of the transport of the drug via mutant PfCRT.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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