Synthesis and biological evaluation of various new bis-isoxazoline derivatives as potential antioxidant additives

Abstract

1,4-Bis[4-(4-benzoyl-5-phenylisoxazol-3-yl)-3-methyl-1-phenylpyrazol-5-yloxy]benzene and its derivatives were synthesised. The antioxidant activities of these compounds were investigated in vitro assay systems, such as lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl, 2,2′-azino-bis(3-ethyl-1,3-benzothiazoline-6-sulfonic acid), superoxide, hydroxyl radicals scavenging and reducing power assay. The results show that the target compounds with nitro- and chloro-substituents at the 4-position of the benzene ring had more effective antioxidant power and better radical scavenging activity (RSA) (%) values when compared to those of butylated hydroxytoluene, trolox, caffeic acid and ascorbic acid, respectively..