Coronavirus Disease 2019 (COVID-19) Outbreak Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) P.1 Lineage in a Long-Term Care Home After Implementation of a Vaccination Program—Ontario, Canada, April

Coronavirus Disease 2019 (COVID-19) Outbreak Associated With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) P.1 Lineage in a Long-Term Care Home After Implementation of a Vaccination Program—Ontario, Canada, April–May 2021

Published:2021-07-08 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Williams Chantal¹,Al-Bargash Dana²,Macalintal Celeste³,Stuart Rebecca²,Seth Anu²,Latham Julienne³,Gitterman Leah¹,Fedsin Stephanie¹,Godoy Marion³,Kozak Robert⁴⁵,Guthrie Jennifer L⁶,Wood Heidi⁷,McGeer Allison⁵⁸⁹,Hota Susy¹¹⁰,Rea Elizabeth²⁹

Affiliation:

1. Infection Prevention and Control Department, University Health Network, Toronto, Ontario, Canada

2. Toronto Public Health, Toronto, Ontario, Canada

3. Responsive Management, Toronto, Ontario, Canada

4. Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

5. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

6. Public Health Ontario Laboratory, Toronto, Ontario, Canada

7. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

8. Department of Microbiology, Sinai Health System, Toronto, Ontario, Canada

9. Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

10. Department of Medicine, University of Toronto, Toronto, Ontario, Canada

Abstract

Abstract In a P.1 coronavirus disease 2019 (COVID-19) outbreak in a long-term care home, vaccine effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was 52.5% (95% confidence interval: 26.9%–69.1%) in residents and 66.2% (2.3%–88.3%) in staff. Vaccine effectiveness against severe illness was 78.6% (47.9%–91.2%) in residents. Two of 19 vaccinated resident case patients died. Outbreak management required both vaccination and infection control measures.

Funder

Public Health Agency of Canada

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab617/40836133/ciab617.pdf

Reference12 articles.

1. Incident SARS-CoV-2 infection among mRNA-vaccinated and unvaccinated nursing home residents;White;N Engl J Med

2. Early success of COVID-19 vaccines in nursing homes—will it stick?;Ouslander;J Am Geriatr Soc

3. Reduced BNT162b2 mRNA vaccine response in SARS-CoV-2-naive nursing home residents;Canaday;Clin Infect Dis

4. COVID-19 outbreak associated with a SARS-CoV-2 R.1 lineage variant in a skilled nursing facility after vaccination program - Kentucky, March 2021;Cavanaugh;MMWR Morb Mortal Wkly Rep,2021

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Epidemiology of COVID-19 outbreaks in aged care facilities during postvaccine period: a systematic review and meta-analysis;BMJ Open;2024-03

2. “Flying a plane and building it at the same time”: Lessons learned from the dynamic implementation of mass vaccination clinics in the Region of Waterloo, Ontario, Canada;Health Research Policy and Systems;2023-10-03

3. Determining the Time of Booster Dose Based on the Half-Life and Neutralization Titers against SARS-CoV-2 Variants of Concern in Fully Vaccinated Individuals;Microbiology Spectrum;2023-08-17

4. Vaccines for the Prevention of Coronavirus Disease 2019 in Older Adults;Infectious Disease Clinics of North America;2023-03

5. COVID-19 outbreaks in residential care homes in Hong Kong and effectiveness of vaccine against severe outcomes;Infectious Medicine;2023-03