Retreatment of Chronic Hepatitis C Infection: Real-World Regimens and Outcomes From National Treatment Programs in Three Low- and Middle-Income Countries

Author:

Boeke Caroline E1,Hiebert Lindsey2,Waked Imam3,Tsertsvadze Tengiz4,Sharvadze Lali5,Butsashvili Maia6,Zakalashvili Mamuka7,Naing Win8,Gupta Neil9,Kateera Fredrick9,McClure Craig1,Ward John W2,Ramers Christian B1

Affiliation:

1. Clinton Health Access Initiative, Boston, Massachusetts, USA

2. Coalition for Global Hepatitis Elimination, Task Force for Global Health, Decatur, Georgia, USA

3. Hepatology Department, National Liver Institute, Menoufia University, Shebeen El Kom, Egypt

4. Infectious Diseases, AIDS, and Clinical Immunology Research Center, Tbilisi, Georgia

5. Hepatology Clinic Hepa, Tbilisi, Georgia

6. Clinic Neolab, Tbilisi, Georgia

7. Clinic Mrcheveii, Tbilisi, Georgia

8. Yangon Speciality Hospital, Yangon, Myanmar

9. Partners in Health/ Inshuti Mu Buzima, Kigali, Rwanda

Abstract

Abstract Access to recommended second-line treatments is limited for patients who fail initial hepatitis C virus (HCV) therapy in low- and middle-income countries. Alternative regimens and associated outcomes are not well understood. Through a pooled analysis of national program data in Egypt, Georgia, and Myanmar, we observed SVR rates >90% for alternative retreatment regimens.

Funder

United Kingdom Foreign, Commonwealth and Development Office

Coalition for Global Hepatitis Elimination

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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