The Removal of Airborne Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Other Microbial Bioaerosols by Air Filtration on Coronavirus Disease 2019 (COVID-19) Surge Units

Author:

Conway Morris Andrew12,Sharrocks Katherine3,Bousfield Rachel34,Kermack Leanne5,Maes Mailis5,Higginson Ellen5,Forrest Sally5,Pereira-Dias Joana5,Cormie Claire5,Old Tim3,Brooks Sophie3,Hamed Islam1,Koenig Alicia1,Turner Andrew6,White Paul67,Floto R Andres89,Dougan Gordon5,Gkrania-Klotsas Effrossyni3,Gouliouris Theodore34,Baker Stephen5,Navapurkar Vilas1ORCID

Affiliation:

1. The John Farman ICU, Cambridge University Hospitals, National Health Service (NHS) Foundation Trust, Cambridge, United Kingdom

2. University Division of Anaesthesia, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom

3. Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

4. Clinical Microbiology Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

5. Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom

6. Department of Clinical Engineering, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom

7. Medical Technology Research Centre and School of Medicine, Anglia Ruskin University, Chelmsford, United Kingdom

8. Molecular Immunity Unit, University of Cambridge Department of Medicine, MRC-Laboratory of Molecular Biology, Cambridge, United Kingdom

9. Cambridge Centre for Lung Infection, Royal Papworth Hospital, Cambridge, United Kingdom

Abstract

Abstract Airborne severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detected in a coronavirus disease 19 (COVID-19) ward before activation of HEPA-air filtration but not during filter operation; SARS-CoV-2 was again detected following filter deactivation. Airborne SARS-CoV-2 was infrequently detected in a COVID-19 intensive care unit. Bioaerosol was also effectively filtered.

Funder

Wellcome Trust senior research fellowship to Stephen Baker

National Institute for Health Research Antimicrobial Resistance (NIHR AMR) Research Capital Funding Scheme

Medical Research Council

Cambridge University Hospitals NHS Foundation Trust

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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