The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity

Author:

Pollett Simon D12,Richard Stephanie A12,Fries Anthony C3,Simons Mark P1,Mende Katrin124,Lalani Tahaniyat15ORCID,Lee Tida5,Chi Sharon16,Mody Rupal7,Madar Cristian6,Ganesan Anuradha18,Larson Derek T9,Colombo Christopher J10,Colombo Rhonda1210,Samuels Emily C211,Broder Christopher C11,Laing Eric D12,Smith Darci R12,Tribble David1,Agan Brian K12ORCID,Burgess Timothy H1

Affiliation:

1. Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

2. Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc, Bethesda, Maryland, USA

3. US Air Force School of Aerospace Medicine, Dayton, Ohio, USA

4. Brooke Army Medical Center, Fort Sam, Houston, Texas, USA

5. Naval Medical Center Portsmouth, Portsmouth, Virginia, USA

6. Tripler Army Medical Center, Honolulu, Hawaii, USA

7. William Beaumont Army Medical Center, El Paso, Texas, USA

8. Walter Reed National Military Medical Center, Bethesda, Maryland, USA

9. Fort Belvoir Community Hospital, Fort Belvoir, Virginia, USA

10. Madigan Army Medical Center, Joint Base Lewis-McChord, Washington, USA

11. Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

12. Biological Defense Research Directorate, Naval Medical Research Center, Frederick, Maryland, USA

Abstract

Abstract Little is known about severe acute respiratory syndrome coronavirus 2 “vaccine-breakthrough” infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference12 articles.

1. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine;Polack;N Engl J Med,2020

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