Genomic characterization of SARS-CoV-2 from vaccine breakthrough cases in Allegheny County, Pennsylvania

Author:

Waggle Kady D.,Griffith Marissa P.,Zhu Lei,Cooper Vaughn S.ORCID,Snyder Daniel J.,Srinivasa Vatsala,Phan Tung,Wells Alan,Snyder Graham M.ORCID,Van Tyne Daria,Harrison Lee H.,Marsh Jane W.ORCID

Abstract

We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.

Funder

UPMC

Publisher

Public Library of Science (PLoS)

Subject

Multidisciplinary

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