BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity-Reference-Cited by-同舟云学术

BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity

Published:2021-05-16 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Bailly Benoit¹²,Guilpain Luc³,Bouiller Kevin²⁴,Chirouze Catherine²⁴,N’Debi Melissa⁵,Soulier Alexandre⁶,Demontant Vanessa⁵,Pawlotsky Jean-Michel⁶⁷,Rodriguez Christophe⁵⁶⁷,Fourati Slim⁶⁷

Affiliation:

1. Department of Infectious Disease, University Hospital of Besançon, Besançon, France

2. Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France

3. Department of Medical Laboratory, Hospital of Lons Le Saunier, Lons Le Saunier, France

4. UMR-CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France

5. Genomics Platform, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France

6. Virology Unit, Department of Prevention, Diagnosis and Treatment of Infections, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France

7. Institut Mondor de Recherche Biomédicale, INSERM U955, Université Paris-Est, Créteil, France

Abstract

Abstract We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.

Funder

Ministry of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab446/38830407/ciab446.pdf

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