Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1-Reference-Cited by-同舟云学术

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Phase I pharmacokinetic and pharmacodynamic study of the bioreductive drug RH1

Published:2011-07 Issue:7 Volume:22 Page:1653-1660
ISSN:0923-7534
Container-title:Annals of Oncology
language:en
Short-container-title:Annals of Oncology

Author:

Danson S.J.,Johnson P.,Ward T.H.,Dawson M.,Denneny O.,Dickinson G.,Aarons L.,Watson A.,Jowle D.,Cummings J.,Robson L.,Halbert G.,Dive C.,Ranson M.

Funder

Drug Development Office, Cancer Research UK

Publisher

Elsevier BV

Subject

Oncology,Hematology

Link

http://academic.oup.com/annonc/article-pdf/22/7/1653/459769/mdq638.pdf

Reference32 articles.

1. Enzymology of bioreductive drug activation;Ross;Br J Cancer,1996

2. The role of NAD(P)H:quinone oxidoreductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent E09;Walton;Cancer Commun,1991

3. The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide);Boland;Biochem Pharmacol,1991

4. Cancer therapy with β-lapachone;Pardee;Curr Cancer Drug Targets,2002

5. DT-Diaphorase: a target for novel anticancer drugs;Danson;Cancer Treat Rev,2004

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