Author:
Boland Marion P.,Knox Richard J.,Roberts John J.
Subject
Pharmacology,Biochemistry
Reference32 articles.
1. CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells;Roberts;Biochem Biophys Res Commun,1986
2. A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells;Knox;Biochem Pharmacol,1988
3. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitro-benzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxyl-amino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2);Knox;Biochem Pharmacol,1988
4. DT diaphorase: a historical review;Ernster;Chemica Scripta,1987
5. Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells;Roberts;Biochem Pharmacol,1989
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