An Overview of Analytical Methods for the Quantification of Marbofloxacin in Pharmaceutical, Biological, and Food Matrixes

Abstract

Abstract Background Marbofloxacin (MAR), a second-generation fluoroquinolone, is used in veterinary medicine in the form of tablets. It has a broad spectrum of action, low toxicity, and limited development of bacterial resistance. The analytical methods available in the literature become more important since MAR in tablets does not have a monograph in official compendiums. Objective Our purpose is to review the methods according to the analyzed matrix and place them according to the conditions used in the scope of green analytical chemistry, in addition to discussing possible gaps and opportunities for the development of new methods. Results MAR, being an antimicrobial, presents both physicochemical (93%) and microbiological (7%) methods in the literature. Among the methods found, 53% are for analysis of food matrixes using preferably HPLC and TLC–MS, 27% are for analysis of biological matrixes and 20% are for analysis of pharmaceutical matrixes, and in both HPLC is preferably used. Conclusion Therefore, there is still a gap in the literature in relation to other analytical methods for the analysis of MAR, which are faster, such as microbiological turbidimetry, sustainable, such as miniaturized methods, and ecologically correct, such as those that do not use toxic organic solvents. Highlights A review of the analytical methods available in the literature for assessing the quality of MAR and MAR-based products in which the methods, as well as new opportunities for analysis according to green analytical chemistry, were described and discussed.