Affiliation:
1. Institute of Human Nutrition and Food Science, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
2. Pennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA
Abstract
ABSTRACT
Background
Adaptive thermogenesis (AT) is currently defined as the fat-free mass (FFM)–independent change in resting energy expenditure (REE) in response to caloric restriction (CR) or overfeeding (OF). So far, the impact of changes in the anatomical and molecular composition of FFM on AT has not been addressed.
Objectives
To assess the impact of changes in FFM composition on AT.
Methods
FFM was assessed in 32 healthy young men during controlled 21-d CR and 14 d of subsequent OF. Anatomical (i.e., the organ/tissue level) and molecular (i.e., water, mineral, and protein content and thus body density) composition of FFM were characterized. REE was measured by indirect calorimetry.
Results
With CR, body weight and REE decreased by 4.2 ± 0.9 kg and 173 ± 107 kcal/d, respectively, with corresponding increases of 3.5 ± 1.2 kg and 194 ± 110 kcal/d during OF (P < 0.001 for all changes). Changes in FFM explained 56.7% and 66.7% of weight loss and weight gain, respectively. Weight changes were associated with changes in various anatomical (i.e., masses of skeletal muscle, liver, kidneys, and brain) and molecular components (total body water, protein, and bone minerals) of FFM. After adjustments for changes in FFM only, AT was 116 ± 127 (P < 0.001) and 27 ± 115 kcal/d (NS) with CR and OF, respectively. Adjustments for FFM and its anatomical and molecular composition reduced AT in response to CR to 83 ± 116 and 122 ± 123 kcal/d (P < 0.05 and P < 0.001) whereas during OF, AT became significant at 87 ± 146 kcal/d (anatomical; P < 0.05) and 86 ± 118 kcal/d (molecular; P < 0.001).
Conclusions
Adjusting changes in REE with under- and overfeeding for the corresponding changes in the anatomical and molecular composition of FFM decreased AT after CR and increased AT after OF, but overall adjusted AT was likely not large enough in magnitude to be able to prevent weight loss or resist weight gain.
Funder
German Ministry of Education and Research
German Research Foundation
BMBF
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)
Cited by
22 articles.
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