Prevalence of antimicrobial resistance genes and its association with restricted antimicrobial use in food-producing animals: a systematic review and meta-analysis

Author:

Nobrega Diego B12ORCID,Tang Karen L3,Caffrey Niamh P4,De Buck Jeroen5,Cork Susan C4,Ronksley Paul E6,Polachek Alicia J7,Ganshorn Heather8,Sharma Nishan7,Kastelic John P5,Kellner James D9,Ghali William A3,Barkema Herman W256ORCID

Affiliation:

1. Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada

2. Mastitis Network, Faculty of Veterinary Medicine, University of Montreal, Saint-Hyacinthe, QC, Canada

3. Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

4. Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada

5. Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada

6. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

7. W21C Research and Innovation Centre, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

8. Libraries and Cultural Resources, University of Calgary, Calgary, AB, Canada

9. Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Abstract

Abstract Background There is ongoing debate regarding potential associations between restrictions of antimicrobial use and prevalence of antimicrobial resistance (AMR) in bacteria. Objectives To summarize the effects of interventions reducing antimicrobial use in food-producing animals on the prevalence of AMR genes (ARGs) in bacteria from animals and humans. Methods We published a full systematic review of restrictions of antimicrobials in food-producing animals and their associations with AMR in bacteria. Herein, we focus on studies reporting on the association between restricted antimicrobial use and prevalence of ARGs. We used multilevel mixed-effects models and a semi-quantitative approach based on forest plots to summarize findings from studies. Results A positive effect of intervention [reduction in prevalence or number of ARGs in group(s) with restricted antimicrobial use] was reported from 29 studies for at least one ARG. We detected significant associations between a ban on avoparcin and diminished presence of the vanA gene in samples from animals and humans, whereas for the mecA gene, studies agreed on a positive effect of intervention in samples only from animals. Comparisons involving mcr-1, blaCTX-M, aadA2, vat(E), sul2, dfrA5, dfrA13, tet(E) and tet(P) indicated a reduced prevalence of genes in intervention groups. Conversely, no effects were detected for β-lactamases other than blaCTX-M and the remaining tet genes. Conclusions The available body of scientific evidence supported that restricted use of antimicrobials in food animals was associated with an either lower or equal presence of ARGs in bacteria, with effects dependent on ARG, host species and restricted drug.

Funder

WHO

Alberta Innovates—Technology Futures

NSERC CREATE in Milk Quality

Izaak Walton Killam Memorial Scholarship

Gustav Rosenberger Memorial Fund

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3