Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity-Reference-Cited by-同舟云学术

Roles of the disulfide bond between the variable and the constant domains of rabbit immunoglobulin kappa chains in thermal stability and affinity

Published:2018-05-30 Issue:7-8 Volume:31 Page:243-247
ISSN:1741-0126
Container-title:Protein Engineering, Design and Selection
language:en
Short-container-title:

Author:

Kawade Raiji¹,Akiba Hiroki¹²,Entzminger Kevin³,Maruyama Toshiaki³,Okumura C J³,Tsumoto Kouhei¹²⁴

Affiliation:

1. Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

2. Laboratory of Pharmacokinetic Optimization, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, 7-6-8 Saito-Asagi, Ibaraki City, Osaka, Japan

3. Abwiz Bio Inc., 9823 Pacific Heights Blvd Suite J, San Diego, CA, USA

4. Medical Proteomics Laboratory, Institute of Medical Sciences, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan

Funder

Grants-in-Aid for Scientific Research

University of Tokyo

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,Bioengineering,Biotechnology

Link

http://academic.oup.com/peds/article-pdf/31/7-8/243/26757233/gzy008.pdf

Reference20 articles.

1. Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life

2. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers

3. Examination of Thermal Unfolding and Aggregation Profiles of a Series of Developable Therapeutic Monoclonal Antibodies

4. VH-VL orientation prediction for antibody humanization candidate selection: A case study

5. Design of therapeutic proteins with enhanced stability

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