Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability-Reference-Cited by-同舟云学术

Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

Published:2024-02-14 Issue:1 Volume:16 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Liang Wei-Ching¹,Xi Hongkang¹,Sun Dawei²,D’Ascenzo Luigi²,Zarzar Jonathan³,Stephens Nicole³,Cook Ryan⁴,Li Yinyin⁴,Ye Zhengmao⁴⁵,Matsumoto Marissa²⁶,Payandeh Jian²⁷,Masureel Matthieu²,Wu Yan¹

Affiliation:

1. Department of Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

2. Department of Structural Biology, Genentech Inc, South San Francisco, CA, USA

3. Department of Pharma Technical Development, Genentech Inc, South San Francisco, CA, USA

4. Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA

5. Discovery Science & Technology Department, Gilead Sciences Inc, Foster City, CA, USA

6. Asher Biotherapeutics, South San Francisco, CA, USA

7. Exelixis Inc, Alameda, CA, USA

Funder

internal Genentech funds

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2024.2309685

Reference31 articles.

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4. Rabbit Anti-HIV-1 Monoclonal Antibodies Raised by Immunization Can Mimic the Antigen-Binding Modes of Antibodies Derived from HIV-1-Infected Humans

5. Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic Analysis