Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer

Author:

Belinsky Steven A.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference67 articles.

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2. Greenblatt,M.S., Bennett,W.P., Hollstein,M. and Harris,C.C. ( 1994 ) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. , 54 , 4855 –4878.

3. Merlo,A., Gabrielson,E., Askin,F. and Sidransky,D. ( 1994 ) Frequent loss of chromosome 9 in human primary non-small cell lung cancer. Cancer Res. , 54 , 640 –642.

4. Kamb,A., Gruis,N.A., Weaver-Feldhaus,J., Liu,Q., Harshman,K., Tavtigian,S.V., Stockert,E., Day,R.S.III, Johnson,B.E. and Skolnick,M.H. ( 1994 ) A cell cycle regulator potentially involved in genesis of many tumor types. Science , 264 , 436 –440.

5. Merlo,A., Herman,J.G., Mao,L., Lee,D.J., Gabrielson,E., Burger,P.C., Baylin,S.B. and Sidransky,D. ( 1995 ) 5′CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. , 1 , 633 –634.

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