Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone:in vivostudies using a CYP2A13-humanized mouse model

Author:

Megaraj Vandana,Zhou Xin,Xie Fang,Liu Zhihua,Yang Weizhu,Ding Xinxin

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference31 articles.

1. Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts

2. Biochemistry, Biology, and Carcinogenicity of Tobacco-Specific N-Nitrosamines

3. Hecht S.S. (1980) Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N’-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res., 40, 298–302.

4. Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosainino)-1-(3-pyridyl)-1-butanone and the effect of diet

5. IARC (2007) Smokeless tobacco and some tobacco-specific N-nitrosamine. IARC Monographs on the Evaluation of Carcinogenic Risks to Human, Vol. 89, International Agency for Research on Cancer, Lyon, pp. 421–589.

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