One-Week Kava Dietary Supplementation Increases Both Urinary N- and O-Glucuronides of NNAL, a Lung Carcinogen Major Metabolite, among Smokers

Author:

Hu Qi1,Tang Zhixin2,Lynch Allison1,Freeman Breanne1,Fujioka Naomi3,Salloum Ramzi G.4,Malaty John5,Orlando Frank A.5,Langaee Taimour6,Huo Zhiguang2,Xing Chengguo1ORCID

Affiliation:

1. Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States

2. Department of Biostatistics, Colleges of Public Health & Health Professions and Medicine, University of Florida, Gainesville, Florida 32610, United States

3. Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, United States

4. Department of Health Outcomes & Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

5. Department of Community Health & Family Medicine, College of Medicine, University of Florida, Gainesville, Florida 32610, United States

6. Center for Pharmacogenomics and Precision Medicine, Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States

Funder

National Center for Advancing Translational Sciences

Division of Cancer Prevention, National Cancer Institute

Florida Department of Health

National Center for Complementary and Integrative Health

Publisher

American Chemical Society (ACS)

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