Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant

Author:

Fiorani Paola,Tesauro Cinzia,Mancini Giordano,Chillemi Giovanni,D'A;nnessa Ilda,Graziani Grazia,Tentori Lucio,Muzi Alessia,Desideri Alessandro

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference48 articles.

1. DNA topoisomerases: essential enzymes and lethal targets;Chen;Ann. Rev. Pharmacol. Toxicol.,1994

2. Investigating the biological functions of DNA topoisomerases in eukaryotic cells;Nitiss;Biochim. Biophys. Acta,1998

3. DNA topoisomerases;Wang;Ann. Rev. Biochem.,1996

4. DNA topoisomerases: structure, function, and mechanism;Champoux;Ann. Rev. Biochem.,2001

5. Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani;Das;FEBS Lett.

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