Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo-Reference-Cited by-同舟云学术

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

Published:2018-02-08 Issue:5 Volume:46 Page:2185-2196
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Hassler Matthew R¹,Turanov Anton A¹,Alterman Julia F¹,Haraszti Reka A¹,Coles Andrew H¹,Osborn Maire F¹,Echeverria Dimas¹,Nikan Mehran¹,Salomon William E¹,Roux Loïc¹,Godinho Bruno M D C¹,Davis Sarah M¹,Morrissey David V²,Zamore Phillip D¹,Karumanchi S Ananth³,Moore Melissa J¹,Aronin Neil¹⁴,Khvorova Anastasia¹⁵

Affiliation:

1. RNA Therapeutics Institute, University of Massachusetts Medical School, USA

2. Novartis Institute of Biomedical Research, USA

3. Beth Israel Deaconess Medical Center, Harvard Medical School, USA

4. Department of Medicine, University of Massachusetts Medical School, USA

5. Department of Molecular Medicine, University of Massachusetts Medical School, USA

Funder

CHDI Foundation

Bill and Melissa Gates foundation

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/5/2185/24387930/gky037.pdf

Reference48 articles.

1. Silencing disease genes in the laboratory and the clinic;Watts;J. Pathol.,2012

2. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing;Deleavey;Nucleic Acids Res.,2010

3. Fully 2′-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA;Allerson;J. Med. Chem.,2005

4. Chemical modification of siRNAs to improve serum stability without loss of efficacy;Choung;Biochem. Biophys. Res. Commun.,2006

5. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells;Czauderna;Nucleic Acids Res.,2003

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