The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters
Author:
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/45/11/6350/17756001/gkx218.pdf
Reference61 articles.
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4. Inactivating CUX1 mutations promote tumorigenesis;Chronic Myeloid Disorders Working Group of the International Cancer Genome, C.;Nat. Genet.,2014
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1. CUX1 regulates human hematopoietic stem cell chromatin accessibility via the BAF complex;Cell Reports;2024-05
2. Haploinsufficient Transcription Factors in Myeloid Neoplasms;Annual Review of Pathology: Mechanisms of Disease;2024-01-24
3. Chondroitin and dermatan sulfate exposure induces a wound healing state in fibroblasts through Cux1-mediated SerpinB2 transcriptional repression;2023-08-01
4. Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells;Oncogene;2023-02-01
5. CUX1 Regulates Human Hematopoietic Stem Cell Chromatin Accessibility via the BAF Complex;2023
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