CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia-Reference-Cited by-同舟云学术

CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia

Published:2013-02-07 Issue:6 Volume:121 Page:975-983
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

McNerney Megan E.¹²,Brown Christopher D.¹³,Wang Xiaoyue¹³,Bartom Elizabeth T.⁴,Karmakar Subhradip¹,Bandlamudi Chaitanya¹⁵,Yu Shan¹⁵,Ko Jinkyung⁶,Sandall Barry P.⁶,Stricker Thomas⁷,Anastasi John²,Grossman Robert L.¹⁴,Cunningham John M.⁶,Le Beau Michelle M.¹⁸,White Kevin P.¹³⁹

Affiliation:

1. Institute for Genomics and Systems Biology,

2. Department of Pathology,

3. Department of Human Genetics,

4. Center for Research Informatics,

5. Committee on Genetics, Genomics, and Systems Biology, and

6. Department of Pediatrics, Section of Hematology/Oncology and Stem Cell Transplantation, University of Chicago, Chicago, IL;

7. Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN; and

8. Sections of Hematology/Oncology and

9. Genetic Medicine, University of Chicago, Chicago, IL

Abstract

Key PointsCUX1 is a transcription factor encoded on a region of chromosome 7 that is frequently deleted in high-risk acute myeloid leukemia. Haploinsufficiency of CUX1/cut promotes hematopoietic overgrowth in both Drosophila melanogaster and human xenograft mouse models in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/6/975/1368254/zh800613000975.pdf

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