UGT1A1 polymorphism as a prognostic indicator of stage I ovarian clear cell carcinoma patients treated with irinotecan

Author:

Yoshihama Tomoko,Hirasawa Akira,Nomura Hiroyuki,Akahane Tomoko,Nanki Yoshiko,Yamagami Wataru,Kataoka Fumio,Tominaga Eiichiro,Susumu Nobuyuki,Mushiroda Taisei,Aoki Daisuke

Funder

JSPS Bilateral programs KAKENHI Keio Gijuku Academic Development Keio University

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,General Medicine

Reference15 articles.

1. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11;Cancer Res,1991

2. Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis;Cancer Res,2000

3. UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters;J Natl Cancer Inst,2007

4. Polymorphism in the UGT1A1 gene predict adverse effects of irinotecan in the treatment of gynecologic cancer in Japanese patients;J Hum Genet,2013

5. Irinotecan pharmacokinetics/pharmacodynamics and UGT1A1 genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28;Pharmacogenet Genomics,2007

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