Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1*6 and *28

Author:

Minami Hironobu,Sai Kimie,Saeki Mayumi,Saito Yoshiro,Ozawa Shogo,Suzuki Kazuhiro,Kaniwa Nahoko,Sawada Jun-ichi,Hamaguchi Tetsuya,Yamamoto Noboru,Shirao Kuniaki,Yamada Yasuhide,Ohmatsu Hironobu,Kubota Kaoru,Yoshida Teruhiko,Ohtsu Atsushi,Saijo Nagahiro

Publisher

Ovid Technologies (Wolters Kluwer Health)

Subject

Genetics (clinical),Genetics,Molecular Biology,Molecular Medicine,General Pharmacology, Toxicology and Pharmaceutics

Reference32 articles.

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3. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes;Iyer;J Clin Invest,1998

4. Phase I and pharmacokinetic study of the camptothecin derivative irinotecan, administered on a weekly schedule in cancer patients;De Forni;Cancer Res,1994

5. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea;Gupta;Cancer Res,1994

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