Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)-Reference-Cited by-同舟云学术

Associations of life course obesity with endometrial cancer in the Epidemiology of Endometrial Cancer Consortium (E2C2)

Published:2023-04-08 Issue:4 Volume:52 Page:1086-1099
ISSN:0300-5771
Container-title:International Journal of Epidemiology
language:en
Short-container-title:

Author:

Harvey Summer V¹^ORCID,Wentzensen Nicolas¹,Bertrand Kimberly²^ORCID,Black Amanda¹,Brinton Louise A¹,Chen Chu³,Costas Laura⁴⁵,Dal Maso Luigino⁶^ORCID,De Vivo Immaculata⁷,Du Mengmeng⁸,Garcia-Closas Montserrat¹,Goodman Marc T⁹,Gorzelitz Jessica¹⁰,Johnson Lisa³,Lacey James V¹¹,Liao Linda¹⁰,Lipworth Loren¹²,Lissowska Jolanta¹³,Miller Anthony B¹⁴,O'Connell Kelli⁸,O’Mara Tracy A¹⁵,Ou Xiao¹²,Palmer Julie R²,Patel Alpa V¹⁶,Paytubi Sonia⁴,Pelegrina Beatriz⁴⁵,Petruzella Stacey⁸,Prizment Anna¹⁷,Rohan Thomas¹⁸,Sandin Sven¹⁹^ORCID,Setiawan Veronica Wendy²⁰,Sinha Rashmi¹⁰,Trabert Britton¹^ORCID,Webb Penelope M²¹^ORCID,Wilkens Lynne R²²,Xu Wanghong²³^ORCID,Yang Hannah P¹,Zheng Wei¹²^ORCID,Clarke Megan A¹

Affiliation:

1. Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD, USA

2. Slone Epidemiology Center, at Boston University , Boston, MA, USA

3. Division of Public Health Sciences, Fred Hutchinson Cancer Center , Seattle, WA, USA

4. Cancer Epidemiology Research Programme IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat , Barcelona, Spain

5. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) , Madrid, Spain

6. Cancer Epidemiology Unit, Centro di Riferimento Oncologico , Aviano, Italy

7. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School , Boston, MA, USA

8. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, NY, USA

9. Cedars-Sinai Cancer and Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA, USA

10. Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute , Bethesda, MD, USA

11. Division of Health Analytics, Department of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA, USA

12. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center , Nashville, TN, USA

13. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Institute of Oncology , Warsaw, Poland

14. Dalla Lana School of Public Health, University of Toronto , Toronto, ON, Canada

15. Cancer Research Program, QIMR Berghofer Medical Research Institute , Brisbane, QLD, Australia

16. Department of Population Science, American Cancer Society , Atlanta, GA, USA

17. Division of Hematology, Oncology and Transplantation, University of Minnesota , Minneapolis, MN, USA

18. Department of Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, NY, USA

19. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet , Stockholm, Sweden

20. Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California , Los Angeles, CA, USA

21. Population Health Department, QIMR Berghofer Medical Research Institute , Brisbane, QLD, Australia

22. Epidemiology Program, University of Hawaii Cancer Center , Honolulu, HI, USA

23. Department of Epidemiology, Fudan University School of Public Health , Shanghai, China

Abstract

Abstract Background Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life obesity with EC are inconclusive. We evaluated associations of young adulthood (18–21 years) and adulthood (at enrolment) body mass index (BMI) and weight change with EC risk in the Epidemiology of Endometrial Cancer Consortium (E2C2). Methods We pooled data from nine case-control and 11 cohort studies in E2C2. We performed multivariable logistic regression analyses to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for BMI (kg/m2) in young adulthood and adulthood, with adjustment for BMI in adulthood and young adulthood, respectively. We evaluated categorical changes in weight (5-kg increments) and BMI from young adulthood to adulthood, and stratified analyses by histology, menopausal status, race and ethnicity, hormone replacement therapy (HRT) use and diabetes. Results We included 14 859 cases and 40 859 controls. Obesity in adulthood (OR = 2.85, 95% CI = 2.47–3.29) and young adulthood (OR = 1.26, 95% CI = 1.06–1.50) were positively associated with EC risk. Weight gain and BMI gain were positively associated with EC; weight loss was inversely associated with EC. Young adulthood obesity was more strongly associated with EC among cases diagnosed with endometrioid histology, those who were pre/perimenopausal, non-Hispanic White and non-Hispanic Black, among never HRT users and non-diabetics. Conclusions Young adulthood obesity is associated with EC risk, even after accounting for BMI in adulthood. Weight gain is also associated with EC risk, whereas weight loss is inversely associated. Achieving and maintaining a healthy weight over the life course is important for EC prevention efforts.

Funder

Intramural Research Programs of the NCI

NIH

Department of Health and Human Services

National Cancer Institute

Data Coordinating Center

National Cancer Institute, National Institutes of Health

National Health and Medical Research Council of Australia

Cancer Council Tasmania

National Institutes of Health

Publisher

Oxford University Press (OUP)