Indicators of cure for women living after uterine and ovarian cancers: a population-based study-Reference-Cited by-同舟云学术

Indicators of cure for women living after uterine and ovarian cancers: a population-based study

Published:2024-04-15 Issue:9 Volume:193 Page:1224-1232
ISSN:0002-9262
Container-title:American Journal of Epidemiology
language:en
Short-container-title:

Author:

Giudici Fabiola¹^ORCID,De Paoli Angela²^ORCID,Toffolutti Federica¹^ORCID,Guzzinati Stefano²^ORCID,Francisci Silvia³^ORCID,Bucchi Lauro⁴^ORCID,Gatta Gemma⁵^ORCID,Demuru Elena⁶^ORCID,Mallone Sandra³^ORCID,Cin Antonella Dal²,Caldarella Adele⁷^ORCID,Cuccaro Francesco⁸^ORCID,Migliore Enrica⁹^ORCID,Gambino Maria Letizia¹⁰,Ravaioli Alessandra⁴^ORCID,Puppo Antonella¹¹,Ferrante Margherita¹²^ORCID,Carrozzi Giuliano¹³,Stracci Fabrizio¹⁴^ORCID,Musolino Antonino¹⁵^ORCID,Gasparotti Cinzia¹⁶,Cavallo Rossella¹⁷^ORCID,Mazzucco Walter¹⁸^ORCID,Vitale Maria Francesca¹⁹,Cascone Giuseppe²⁰^ORCID,Ballotari Paola²¹^ORCID,Ferretti Stefano²²^ORCID,Mangone Lucia²³^ORCID,Rizzello Roberto Vito²⁴^ORCID,Sampietro Giuseppe²⁵^ORCID,Mian Michael²⁶^ORCID,Boschetti Lorenza²⁷^ORCID,Galasso Rocco²⁸^ORCID,Bella Francesca²⁹,Piras Daniela³⁰^ORCID,Sessa Alessandra³¹,Seghini Pietro³²^ORCID,Fanetti Anna Clara³³,Pinna Pasquala³⁴,De Angelis Roberta⁶^ORCID,Serraino Diego¹^ORCID,Maso Luigino Dal¹^ORCID, ,Crocetti Emanuele,Rossi Silvia,Tavilla Andrea,Botta Laura,Contiero Paolo,Tagliabue Giovanna,Capocaccia Riccardo,Rugge Massimo,Manneschi Gianfranco,Bruno Danila,Rosso Stefano,Taborelli Martina,Lanzoni Monica,Falcini Fabio,Casella Claudia,Di Prima Alessia,Cirilli Claudia,Bianconi Fortunato,Michiara Maria,Maifredi Giovanni,Frasci Giuseppe,Ravazzolo Barbara,Fusco Mario,Rollo Concetta Patrizia,Giacomazzi Erica,Bisceglia Isabella,Adalgisa Maria,Ghisleni Silvia,Vittadello Fabio,Marguati Stefano,Del Riccio Luciana,Colanino Antonino Ziino,Biddau Giovanna,Merola Maddalena,Prazzoli Rita,Giumelli Paola,Bosu Roberta

Affiliation:

1. Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Cancer Epidemiology Unit, , 33081 Aviano , Italy

2. Azienda Zero Epidemiological Department, , 35132 Padua , Italy

3. National Institute of Health National Centre for Disease Prevention and Health Promotion, , 00161 Rome , Italy

4. Romagna Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori Emilia-Romagna Cancer Registry, , Meldola, 47121 Forlì , Italy

5. Fondazione IRCCS Istituto Nazionale dei Tumori di Milano Evaluative Epidemiology Unit, Department of Research, , 20133 Milano , Italy

6. National Institute of Health Department of Oncology and Molecular Medicine, , 00161 Rome , Italy

7. Institute for cancer research, prevention and clinical network Tuscany Cancer Registry, , 50139 Florence , Italy

8. Section of the Cancer Registry of Puglia Local Health Unit of Barletta-Andria-Trani, , 76121 Barletta , Italy

9. Centro di Riferimento per l'Epidemiologia e la Prevenzione Oncologica (CPO) Piemonte and University of Turin Piedmont Cancer Registry, , 10123 Turin , Italy

10. S.S. Epidemiologia Registri Specializzati e Reti di Patologia Registro tumori ATS Insubria (Provincia di Como e Varese), , 21100 Varese , Italy

11. IRCCS Ospedale Policlinico San Martino Liguria Cancer Registry, , 16132 Genova , Italy

12. Azienda Ospedaliero-Universitaria Policlinico G. Rodolico-San Marco Registro tumori integrato di Catania-Messina-Enna, Igiene Ospedaliera, , 95123 Catania , Italy

13. Local Health Authority Emilia-Romagna Cancer Registry, Modena Unit, Public Health Department, , 41126 Modena , Italy

14. University of Perugia Umbria Cancer Registry, Public Health Section, Department of Medicine and Surgery, , 06123 Perugia , Italy

15. University Hospital of Parma Emilia-Romagna Cancer Registry, Parma Unit, Medical Oncology Unit, , 43126 Parma , Italy

16. Struttura Semplice Epidemiologia Registro tumori ATS Brescia, , ATS Brescia, 25124 Brescia , Italy

17. Cancer Registry Azienda Sanitaria Locale (ASL) Salerno , Dipartimento di Prevenzione, 84124 Salerno, Italy

18. Azienda Ospedaliera Universitaria Policlinico (AOUP) di Palermo Clinical Epidemiology and Cancer Registry Unit, , 90127 Palermo , Italy

19. Registro Tumori ASL Napoli 3 Sud , 80031 Napoli , Italy

20. Registro Tumori Azienda Sanitaria Provinciale (ASP) Ragusa, Dipartimento di Prevenzione, , 97100 Ragusa , Italy

21. ATS Val Padana Osservatorio Epidemiologico, , 46100 Mantova , Italy

22. Local Health Authority, Ferrara, and University of Ferrara Emilia-Romagna Cancer Registry, Ferrara Unit, , 44121 Ferrara , Italy

23. Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia Emilia-Romagna Cancer Registry, Reggio Emilia Unit, Epidemiology Unit, , 42122 Reggio Emilia , Italy

24. Unit of Clinical Epidemiology Trento Province Cancer Registry, , 38123 Trento , Italy

25. Agenzia di Tutela della Salute Bergamo Cancer Registry, Epidemiological Service, , 24121 Bergamo , Italy

26. Lehrkrankenhaus der Paracelsus Medizinischen Privatuniversität Innovation, Research and Teaching Service (SABES-ASDAA), , 39100 Bolzano-Bozen , Italy

27. Cancer Registry of the Province of Pavia , 27200 Pavia , Italy

28. IRCCS Centro di Riferimento Oncologico di Basilicata (CROB) Unit of Regional Cancer Registry, Clinical Epidemiology and Biostatistics, , 85028 Rionero in Vulture , Italy

29. Provincial Health Authority of Siracusa Siracusa Cancer Registry, , 96100 Siracusa , Italy

30. ASL Nord Sardegna Cancer Registry, , 07100 Sassari , Italy

31. Monitoraggio rischio ambientale e Registro Tumori ASL Caserta, 81100 Caserta, Italy

32. AUSL Piacenza Emilia-Romagna Cancer Registry, Piacenza Unit, Public Health Department, , 29100 Piacenza , Italy

33. Agenzia di Tutela della Salute della Montagna Sondrio Cancer Registry, , 23100 Sondrio , Italy

34. ASL Nuoro Nuoro Cancer Registry, RT Nuoro, Servizio Igiene e Sanità Pubblica, , 08100 Nuoro , Italy

Abstract

Abstract This study aims to estimate long-term survival, cancer prevalence, and several cure indicators for Italian women with gynecological cancers. Thirty-one cancer registries, representing 47% of the Italian female population, were included. Mixture cure models were used to estimate net survival, cure fraction, time to cure (when 5-year conditional net survival becomes > 95%), cure prevalence (women who will not die of cancer), and already cured (living longer than time to cure). In 2018, 0.4% (121 704) of Italian women were alive after diagnosis of corpus uteri cancer, 0.2% (52 551) after cervical cancer, and 0.2% (52 153) after ovarian cancer. More than 90% of patients with uterine cancers and 83% with ovarian cancer will not die from their neoplasm (cure prevalence). Women with gynecological cancers have a residual excess risk of death <5% at 5 years after diagnosis. The cure fraction was 69% for corpus uteri, 32% for ovarian, and 58% for cervical cancer patients. Time to cure was ≤10 years for women with gynecological cancers aged <55 years; 74% of patients with cervical cancer, 63% with corpus uteri cancer, and 55% with ovarian cancer were already cured. These results can contribute to improving follow-up programs for women with gynecological cancers and supporting efforts against discrimination of already cured ones. This article is part of a Special Collection on Gynecological Cancers.

Funder

Italian Association for Cancer Research

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/aje/advance-article-pdf/doi/10.1093/aje/kwae044/58657329/kwae044.pdf

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