Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast-Reference-Cited by-同舟云学术

Tschimganine has different targets for chronological lifespan extension and growth inhibition in fission yeast

Published:2022-04-13 Issue:6 Volume:86 Page:775-779
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Ohtsuka Hokuto¹^ORCID,Matsumoto Takuma¹,Mochida Takahiro¹,Shimasaki Takafumi¹,Shibuya Masatoshi²,Yamamoto Yoshihiko²,Aiba Hirofumi¹^ORCID

Affiliation:

1. Laboratory of Molecular Microbiology, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Aichi, Japan

2. Laboratory of Molecular Design, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan

Abstract

ABSTRACT Tschimganine inhibits growth and extends the chronological lifespan in Schizosaccharomyces pombe. We synthesized a Tschimganine analog, Mochimganine, which extends the lifespan similar to Tschimganine but exhibits a significantly weaker growth inhibition effect. Based on the comparative analysis of these compounds, we propose that Tschimganine has at least 2 targets: one extends the lifespan and the other inhibits growth.

Funder

Japan Society for the Promotion of Science

Publisher

Informa UK Limited

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbac051/43608965/zbac051.pdf

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