Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration-Reference-Cited by-同舟云学术

Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration

Published:2018-05-31 Issue:13 Volume:46 Page:6576-6591
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Bao Lei¹,Chen Yan¹,Lai Hsien-Tsung²,Wu Shwu-Yuan²³,Wang Jennifer E¹,Hatanpaa Kimmo J¹,Raisanen Jack M¹,Fontenot Miles⁴,Lega Bradley⁵,Chiang Cheng-Ming²³⁶,Semenza Gregg L⁷,Wang Yingfei¹⁸,Luo Weibo¹⁶^ORCID

Affiliation:

1. Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA

2. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX 75390, USA

3. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA

4. Medical Scientist Training Program, UT Southwestern Medical Center, Dallas, TX 75390, USA

5. Department of Neurological Surgery, UT Southwestern Medical Center, Dallas, TX 75390, USA

6. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA

7. Vascular Program, The Johns Hopkins Institute for Cell Engineering, Baltimore, MD 21205, USA

8. Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX 75390, USA

Funder

Welch Foundation

National Institutes of Health

Susan G. Komen

Cancer Prevention and Research Institute of Texas

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/13/6576/25227897/gky449.pdf

Reference43 articles.

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2. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy;Semenza;Trends Pharmacol. Sci.,2012

3. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway;Kallio;J. Biol. Chem.,1999

4. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway;Huang;Proc. Natl. Acad. Sci. U.S.A.,1998

5. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation;Jaakkola;Science,2001

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