This book provides a groundbreaking approach to critical epidemiology for understanding the complexity of the health process and studying the social determination of health. It presents a powerful critique of Cartesian health sciences; the flaws of the “functional health determinants” model; and reductionist approaches to health statistics, qualitative research, and conventional health geography. It is a consolidated and well-sustained text that explains the role of social–gender–ethnic relations in the reproduction of health inequity, proposing a new paradigm with indispensible concepts and methodological means to develop a new understanding of health as a socially determined and distributed process. It combines the strengths of scientific traditions of the North and South to bring forward a new understanding and application of qualitative and quantitative (statistical) evidence that goes beyond the limits of conventional epidemiology—public and population health. The book presents alternative conceptions and tools for constructing deep prevention. It provides a neo-humanist conception of the role of health and life sciences that assumes critical, intercultural, and transdisciplinary thinking as a fundamental tool beyond the limiting elitist framework of positivist reasoning. It is an important source of fresh ideas and practical instruments for teaching, research, and agency, based on a renewed conception of the relation between nature, society, health, and environmental problems.