Isolation and characterization of zinc coproporphyrin I: a major fluorescent component in meconium-Reference-Cited by-同舟云学术

Isolation and characterization of zinc coproporphyrin I: a major fluorescent component in meconium

Published:1991-07-01 Issue:7 Volume:37 Page:1173-1177
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Horiuchi Kentaro¹,Adachi Kyoko¹²,Fujise Yutaka¹,Naruse Hireo³,Sumimoto Kazuhiro³,Kanayama Naohiro³,Terao Toshihiko³

Affiliation:

1. Department of Chemistry, Hamamatsu University School of Medicine, Japan

2. Marine Biotechnology Institute,, Shimizu,424-91, Japan

3. Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Japan

Abstract

Abstract We isolated a substance from an organic extract of meconium (in neutral pH) that exhibited a porphyrin-like fluorescence peak at 580 nm on excitation at 405 nm and deduced its structure. Spectrometric data suggest that the substance is not free coproporphyrin I or free coproporphyrin III, but is a chelate of coproporphyrin I with Zn2+. We also detected a chelate of coproporphyrin III with Zn2+ by HPLC. These substances may be useful as new indicators of the presence of meconium.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/37/7/1173/32744926/clinchem1173.pdf

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