Usefulness of Serum Lipase, Esterase, and Amylase Estimation in the Diagnosis of Pancreatitis—a Comparison

Abstract

Abstract Sera of 19 individuals with clinically established pancreatitis were analyzed for lipase activity on emulsion-type and aqueous substrates. Serum amylase concentrations were compared. Results obtained on the first and subsequent days of hospitalization clearly indicated that methods for lipase determination in which an emulsion-type substrate is used are of the greatest aid in diagnosing pancreatitis (90 to 92% of patients with pancreatitis had supranormal results). Amylase determinations were nearly as useful as an index (78% correlation), but "lipase" values obtained with methods in which aqueous substrates are used had limited clinical usefulness (29 and 32% correlation). Serum lipase elevations in cases of pancreatitis were generally greater than amylase elevations, with some exceptions. Serum lipase should be determined with a method in which emulsion-type substrates are used. Lipase and amylase values supplement one another.