Capillary electrophoresis system for hemoglobin A1c determinations evaluated-Reference-Cited by-同舟云学术

Capillary electrophoresis system for hemoglobin A1c determinations evaluated

Published:1997-04-01 Issue:4 Volume:43 Page:644-648
ISSN:0009-9147
Container-title:Clinical Chemistry
language:en
Short-container-title:

Author:

Doelman Cees J A¹,Siebelder Carla W M¹,Nijhof Wim A¹,Weykamp Cas W¹,Janssens Jacques²,Penders Theo J¹

Affiliation:

1. Department of Clinical Chemistry and Hematology, Queen Beatrix Hospital, Beatrixpark 1, 7101 BN Winterswijk, The Netherlands

2. Analis S.A., 14 Rue Dewez, B 5000 Namur, Belgium

Abstract

Abstract Hb A1c is the analyte of choice for monitoring metabolic control in patients with diabetes mellitus. Here we present a new analytical technique for measuring Hb A1c, capillary electrophoresis. The Hb A1c determination is not influenced by the labile Hb A1c fraction or by carbamylated or acetylated hemoglobin derivatives. Also, hemoglobin variants (Hb F, Hb S, and Hb C) do not interfere. This new application of capillary electrophoresis seems to be a valuable analytical tool for measuring Hb A1c in the clinical laboratory.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Link

http://academic.oup.com/clinchem/article-pdf/43/4/644/32718201/clinchem0644.pdf

Reference20 articles.

1. Long-Term Complications of Diabetes Mellitus

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4. Influence of hemoglobin variants and derivatives on glycohemoglobin determinations, as investigated by 102 laboratories using 16 methods

5. Hemoglobins S and C: reference values for glycohemoglobin in heterozygous, double heterozygous and homozygous subjects, as established by 13 methods

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