Age of Speech Onset in Autism Relates to Structural Connectivity in the Language Network

Author:

Barbeau Elise B123,Klein Denise123,Soulières Isabelle4,Petrides Michael125,Bernhardt Boris2,Mottron Laurent67ORCID

Affiliation:

1. Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada

2. Neurology and Neurosurgery Department, McGill University, Montreal, QC H3A 2B4, Canada

3. Center for Research on Brain, Language and Music (CRBLM), Montreal, QC H3G 2A8, Canada

4. Department of Psychology, Université du Québec à Montreal, Montreal, QC H2X 3P2, Canada

5. Department of Psychology, McGill University, Montreal, QC H3A 1G1, Canada

6. Département de Psychiatrie et d’addictologie, de l'Université de Montréal, Montréal, QC H3T 1J4, Canada

7. Centre de recherche du CIUSSS-NIM, Montreal, QC H1E 1A4, Canada

Abstract

Abstract Speech onset delays (SOD) and language atypicalities are central aspects of the autism spectrum (AS), despite not being included in the categorical diagnosis of AS. Previous studies separating participants according to speech onset history have shown distinct patterns of brain organization and activation in perceptual tasks. One major white matter tract, the arcuate fasciculus (AF), connects the posterior temporal and left frontal language regions. Here, we used anatomical brain imaging to investigate the properties of the AF in adolescent and adult autistic individuals with typical levels of intelligence who differed by age of speech onset. The left AF of the AS group showed a significantly smaller volume than that of the nonautistic group. Such a reduction in volume was only present in the younger group. This result was driven by the autistic group without SOD (SOD−), despite their typical age of speech onset. The autistic group with SOD (SOD+) showed a more typical AF as adults relative to matched controls. This suggests that, along with multiple studies in AS-SOD+ individuals, atypical brain reorganization is observable in the 2 major AS subgroups and that such reorganization applies mostly to the language regions in SOD− and perceptual regions in SOD+ individuals.

Funder

Marcel & Rolande Gosselin Research Chair in Autism at the University of Montreal

Canadian Institutes of Health Research Postdoctoral Fellowship

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3