A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons-Reference-Cited by-同舟云学术

A Composite Sketch of Fast-Spiking Parvalbumin-Positive Neurons

Published:2020 Issue:1 Volume:1 Page:
ISSN:2632-7376
Container-title:Cerebral Cortex Communications
language:en
Short-container-title:

Author:

Bartholome Odile¹^ORCID,de la Brassinne Bonardeaux Orianne¹,Neirinckx Virginie¹,Rogister Bernard¹²

Affiliation:

1. GIGA-Neurosciences, University of Liege, 4000 Liège, Belgium

2. Neurology Department, CHU, Academic Hospital, University of Liege, 4000 Liège, Belgium

Abstract

Abstract Parvalbumin-positive neurons are inhibitory neurons that release GABA and are mostly represented by fast-spiking basket or chandelier cells. They constitute a minor neuronal population, yet their peculiar profiles allow them to react quickly to any event in the brain under normal or pathological conditions. In this review, we will summarize the current knowledge about the fundamentals of fast-spiking parvalbumin-positive neurons, focusing on their morphology and specific channel/protein content. Next, we will explore their development, maturation, and migration in the brain. Finally, we will unravel their potential contribution to the physiopathology of epilepsy.

Funder

University of Liège

Fond Léon Fredericq

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Link

http://academic.oup.com/cercorcomms/advance-article-pdf/doi/10.1093/texcom/tgaa026/33406900/tgaa026.pdf

Reference198 articles.

1. Electrical synapses enhance and accelerate interneuron recruitment in response to coincident and sequential excitation;Alcami;Front Cell Neurosci.,2018

2. GABA Bouton subpopulations in the human dentate gyrus are differentially altered in mesial temporal lobe epilepsy;Alhourani;J Neurophysiol.,2020