Affiliation:
1. Department of Anatomy, 2nd Medical Faculty, Charles University Prague, Czech Republic. martin.salaj@lfmotol.cuni.cz
Abstract
The calcium binding protein parvalbumin (PV) in the mammalian neocortex is expressed in a subpopulation of cortical GABAergic inhibitory interneurons. PV – producing interneurons represent the largest subpopulation of neocortical inhibitory cells, exhibit mutual chemical and electrical synaptic contacts and are well known to generate gamma oscillation. This review summarizes basic data of the distribution, afferent and efferent connections and physiological properties of parvalbumin expressing neurons in the neocortex. Basic data about participation of PV-positive neurons in cortical microcircuits are presented. Autaptic connections, metabolism and perineuronal nets (PNN) of PV positive neurons are also discussed.
Publisher
Institute of Physiology of the Czech Academy of Sciences
Subject
General Medicine,Physiology
Reference121 articles.
1. Filimonov IN. Comparative anatomy of the cerebral cortex of mammals. Paleocortex. Archicortex and intermediate cortex. 1949, Moscow: Publ. Hause of the Acad. Med. Sci., Moscow.
2. Brodmann K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. 1909, Leipzig: Leipzig: Barth.
3. Mountcastle VB. The columnar organization of the neocortex. Brain 1997;120,701-722. https://doi.org/10.1093/brain/120.4.701
4. Wiesel TN and Hubel DH. Ordered arrangement of orientation columns in monkeys lacking visual experience. J Comp Neurol, 1974;158:307-318. https://doi.org/10.1002/cne.901580306
5. Brodal P. The Central nervous System. 1992: Oxford University Press, p.464.