Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic

Author:

Shoaib Ahmad1ORCID,Van Spall Harriette G C2345,Wu Jianhua67ORCID,Cleland John G F8,McDonagh Theresa A9ORCID,Rashid Muhammad1ORCID,Mohamed Mohamed O1,Ahmed Fozia Z10,Deanfield John11,de Belder Mark12,Gale Chris P6713ORCID,Mamas Mamas A1ORCID

Affiliation:

1. Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, Stoke-on-Trent, UK

2. Department of Medicine, McMaster University, Hamilton, Canada

3. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada

4. Population Health Research Institute, Hamilton, Canada

5. ICES, McMaster University, Hamilton, Canada

6. Leeds Institute for Data Analytics, University of Leeds, Leeds, UK

7. Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK

8. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK

9. School of Cardiovascular Medicine, Kings College, London, UK

10. Department of Cardiology, Manchester University Hospitals NHS Trust, Manchester, UK

11. Institute of Cardiovascular Sciences, University College London, London, UK

12. National Institute for Cardiovascular Outcomes Research, Barts Health NHS Trust, London, UK

13. Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

Abstract

Abstract Aims We hypothesized that a decline in admissions with heart failure during COVID-19 pandemic would lead to a reciprocal rise in mortality for patients with heart failure in the community. Methods and results We used National Heart Failure Audit data to identify 36 974 adults who had a hospital admission with a primary diagnosis of heart failure between February and May in either 2018, 2019, or 2020. Hospital admissions for heart failure in 2018/19 averaged 160/day but were much lower in 2020, reaching a nadir of 64/day on 27 March 2020 [incidence rate ratio (IRR): 0.40, 95% confidence interval (CI): 0.38–0.42]. The proportion discharged on guideline-recommended pharmacotherapies was similar in 2018/19 compared to the same period in 2020. Between 1 February–2020 and 31 May 2020, there was a 29% decrease in hospital deaths related to heart failure (IRR: 0.71, 95% CI: 0.67–0.75; estimated decline of 448 deaths), a 31% increase in heart failure deaths at home (IRR: 1.31, 95% CI: 1.24–1.39; estimated excess 539), and a 28% increase in heart failure deaths in care homes and hospices (IRR: 1.28, 95% CI: 1.18–1.40; estimated excess 189). All-cause, inpatient death was similar in the COVID-19 and pre-COVID-19 periods [odds ratio (OR): 1.02, 95% CI: 0.94–1.10]. After hospital discharge, 30-day mortality was higher in 2020 compared to 2018/19 (OR: 1.57, 95% CI: 1.38–1.78). Conclusion Compared with the rolling daily average in 2018/19, there was a substantial decline in admissions for heart failure but an increase in deaths from heart failure in the community. Despite similar rates of prescription of guideline-recommended therapy, mortality 30 days from discharge was higher during the COVID-19 pandemic period.

Funder

University of Leeds

University of Keele

National Institute of Health Research

Health Quality Improvement Partnership as part of the National Clinical Audit and Patient Outcomes Programme

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Health Policy

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