Acute coronary syndrome registry enrolment status: differences in patient characteristics and outcomes and implications for registry data use (ANZACS-QI 36)

Author:

Earle Nikki J1ORCID,Kerr Andrew J23,Legget Malcolm1,Wu Billy P2,Doughty Robert N14,Poppe Katrina K2

Affiliation:

1. Department of Medicine, University of Auckland, New Zealand

2. School of Population Health, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand

3. Middlemore Hospital, Counties Manukau District Health Board, Auckland, New Zealand

4. Green Lane Cardiovascular Service, Auckland City Hospital, New Zealand

Abstract

Abstract Aims Clinical registry-derived data are widely used to represent patient populations. In New Zealand (NZ), a national registry—the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) registry—aims to include all patients undergoing coronary angiography; other acute coronary syndrome (ACS) patients are also registered but without complete capture. This study compares national hospitalization data of all first-time ACS admissions in NZ with patients in the ANZACS-QI registry, to investigate the use of clinical registry-derived data in research and in assessing clinical care. Methods and results Patients admitted with first-time ACS in the NZ National Hospitalisation Dataset between 1 January 2015 and 31 December 2016 were included. Clinical characteristics and time to 12-month clinical outcomes were compared between patients captured and not-captured in the registry. A total of 16 569 patients were admitted with first-time ACS, median age 69 years, 61% male; 60% (n = 9918) were enrolled in ANZACS-QI. Registry-captured patients were younger, more often male, and with a lower comorbidity burden than non-captured patients. Overall, 16% patients died within 12 months, 15% experienced a non-fatal cardiovascular (CV) readmission, and 28% either died or were readmitted. Patients not captured in the registry were more than twice as likely to have experienced death or a non-fatal CV readmission within 12 months as captured patients. Conclusions First-time ACS patients captured in the ANZACS-QI registry had very different clinical characteristics and outcomes than those not captured. Cardiovascular registry-derived data are dependent on registry design and may not be representative of the wider patient population; this must be considered when using registry-derived data.

Funder

NZ Heart Foundation Research Fellowship

NZ Heart Foundation

Health Research Council

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Health Policy

Reference21 articles.

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