Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls

Author:

Venkatesulu Bhanu P1,Lester Scott2ORCID,Hsieh Cheng-En3ORCID,Verma Vivek4ORCID,Sharon Elad5ORCID,Ahmed Mansoor6,Krishnan Sunil7ORCID

Affiliation:

1. Department of Radiation Oncology, Loyola University Stritch School of Medicine, Chicago, IL, USA

2. Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA

3. Department of Immunology, MD Anderson Cancer Center, Houston, TX, USA

4. Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA

5. Radiation Research Program, Division Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, USA

6. Cancer Therapy Evaluation Program, Division Cancer Treatment and Diagnosis National Cancer Institute, Bethesda, MD, USA

7. Department of Radiation Oncology, Mayo Clinic Florida, Jacksonville, FL, USA

Abstract

Abstract The coronavirus disease-2019 (COVID-19) pandemic caused by SARS-CoV-2 has exacted an enormous toll on healthcare systems worldwide. The cytokine storm that follows pulmonary infection is causally linked to respiratory compromise and mortality in the majority of patients. The sparsity of viable treatment options for this viral infection and the sequelae of pulmonary complications have fueled the quest for new therapeutic considerations. One such option, the long-forgotten idea of using low-dose radiation therapy, has recently found renewed interest in many academic centers. We outline the scientific and logistical rationale for consideration of this option and the mechanistic underpinnings of any potential therapeutic value, particularly as viewed from an immunological perspective. We also discuss the preliminary and/or published results of prospective trials examining low-dose radiation therapy for COVID-19.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference47 articles.

Cited by 14 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3