1. Department of Surgery and Physiology, Cardiovascular R&D Centre (UnIC & RISE), Faculty of Medicine, University of Porto , Porto 4200-319 , Portugal
2. Department of Cardiology, Centro Hospitalar de Vila Nova de Gaia , Vila Nova de Gaia , Portugal
3. Department of Cardiothoracic Surgery, Centro Hospitalar de Sao Joao , Porto , Portugal
4. CNC - Center for Neuroscience and Cell Biology, University of Coimbra , Coimbra , Portugal
5. III: Institute for Interdisciplinary Research, University of Coimbra (IIIUC) , Coimbra , Portugal
6. Department of Medical Sciences, Institute of Biomedicine-iBiMED, University of Aveiro , Aveiro , Portugal