Influence of epicardial adipose tissue inflammation and adipocyte size on postoperative atrial fibrillation in patients after cardiovascular surgery

Author:

Natsui Hiroyuki1ORCID,Watanabe Masaya1ORCID,Yokota Takashi2,Tsuneta Satonori3ORCID,Fumoto Yoshizuki4,Handa Haruka4,Matsushima Shouji5,Koya Jiro1,Nishino Kotaro1,Tatsuta Daishiro1,Koizumi Takuya1,Kadosaka Takahide1,Nakao Motoki1,Koya Taro1,Temma Taro1,Ito Yoichi M.2,Hatanaka Kanako C.6,Hatanaka Yutaka6ORCID,Shingu Yasushige7,Wakasa Satoru7,Miura Shuhei8,Masuda Takahiko8,Nishioka Naritomo8,Naraoka Shuichi8,Ochi Kayoko9,Kudo Tomoko9,Ishikawa Tsugumine9,Anzai Toshihisa1

Affiliation:

1. Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan

2. Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital Sapporo Japan

3. Department of Diagnostic and Interventional Radiology Hokkaido University Hospital Sapporo Japan

4. Department of Molecular Biology, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan

5. Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine Kyushu University Fukuoka Japan

6. Center for Development of Advanced Diagnostics Hokkaido University Hospital Sapporo Japan

7. Department of Cardiovascular Surgery, Faculty of Medicine and Graduate School of Medicine Hokkaido University Sapporo Japan

8. Department of Cardiovascular Surgery, Teine Keijinkai Hospital Sapporo Japan

9. Department of Clinical Laboratory Medicine Teine Keijinkai Hospital Sapporo Japan

Abstract

AbstractEpicardial adipose tissue (EAT) is an active endocrine organ that is closely associated with occurrence of atrial fibrillation (AF). However, the role of EAT in the development of postoperative AF (POAF) remains unclear. We aimed to investigate the association between EAT profile and POAF occurrence in patients who underwent cardiovascular surgery. We obtained EAT samples from 53 patients to evaluate gene expression, histological changes, mitochondrial oxidative phosphorylation (OXPHOS) capacity in the EAT, and protein secretion in EAT‐conditioned medium. EAT volume was measured using computed tomography scan. Eighteen patients (34%) experienced POAF within 7 days after surgery. Although no significant difference was observed in EAT profile between patients with and without POAF, logistic regression analysis identified that the mRNA expression levels of tumor necrosis factor‐alpha (TNF‐α) were positively correlated and adipocyte size in the EAT was inversely correlated with onset of POAF, respectively. Mitochondrial OXPHOS capacity in the EAT was not associated with POAF occurrence; however, it showed an inverse correlation with adipocyte size and a positive correlation with adiponectin secretion. In conclusion, changes in the secretory profile and adipocyte morphology of the EAT, which represent qualitative aspects of the adipose tissue, were present before the onset of AF.

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

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