Detecting human coronary inflammation by imaging perivascular fat

Author:

Antonopoulos Alexios S.1ORCID,Sanna Fabio1ORCID,Sabharwal Nikant2ORCID,Thomas Sheena1ORCID,Oikonomou Evangelos K.1ORCID,Herdman Laura1ORCID,Margaritis Marios13ORCID,Shirodaria Cheerag2,Kampoli Anna-Maria1,Akoumianakis Ioannis1ORCID,Petrou Mario4,Sayeed Rana4ORCID,Krasopoulos George4ORCID,Psarros Constantinos1,Ciccone Patricia1,Brophy Carl M.1,Digby Janet1,Kelion Andrew2ORCID,Uberoi Raman5ORCID,Anthony Suzan5ORCID,Alexopoulos Nikolaos6,Tousoulis Dimitris6ORCID,Achenbach Stephan7,Neubauer Stefan138,Channon Keith M.138,Antoniades Charalambos138ORCID

Affiliation:

1. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

2. Cardiothoracic Directorate, Oxford University Hospitals National Health System (NHS) Foundation Trust, Oxford, UK.

3. Oxford Centre of Research Excellence, British Heart Foundation, Oxford, UK.

4. Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

5. Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

6. 1st Department of Cardiology, Athens University Medical School, Athens, Greece.

7. Medizinische Klinik 2, Universitätsklinikum Erlangen, Erlangen, Germany.

8. Oxford Biomedical Research Centre, National Institute of Health Research, Oxford, UK.

Abstract

Adipocyte size and lipid content in perivascular adipose tissue are inversely associated with coronary inflammation and atherosclerotic plaque burden in human patients.

Funder

National Institute for Health Research

British Heart Foundation

European Commission

BHF Centre of Research Excellence, Oxford

NovoNordisk Foundation

Novo Nordisk Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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