Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank-Reference-Cited by-同舟云学术

Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank

Published:2021-05-14 Issue: Volume: Page:
ISSN:2047-2404
Container-title:European Heart Journal - Cardiovascular Imaging
language:en
Short-container-title:

Author:

Raisi-Estabragh Zahra¹²^ORCID,M'Charrak Amine³,McCracken Celeste¹³^ORCID,Biasiolli Luca³^ORCID,Ardissino Maddalena⁴^ORCID,Curtis Elizabeth M⁵^ORCID,Aung Nay¹²^ORCID,Suemoto Claudia K⁶^ORCID,Mackay Clare⁷^ORCID,Suri Sana⁷^ORCID,Nichols Thomas E⁸⁹^ORCID,Harvey Nicholas C⁵¹⁰^ORCID,Petersen Steffen E¹²^ORCID,Neubauer Stefan³

Affiliation:

1. Centre for Advanced Cardiovascular Imaging, William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK

2. Barts Heart Centre, St Bartholomew’s Hospital, Barts Health NHS Trust, London EC1A 7BE, UK

3. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK

4. Faculty of Medicine, Imperial College London, London SW7 2AZ, UK

5. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

6. Division of Geriatrics, Department of Internal Medicine, University of Sao Paulo Medical School, Sao Paulo, Brazil

7. Department of Psychiatry, University of Oxford, Oxford, UK

8. Nuffield Department of Population Health, Oxford Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, UK

9. Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford OX3 9DU, UK

10. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK

Abstract

Abstract Aims Existing evidence suggests links between brain and cardiovascular health. We investigated associations between cognitive performance and cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank, considering a range of potential confounders. Methods and results We studied 29 763 participants with CMR and cognitive testing, specifically, fluid intelligence (FI, 13 verbal-numeric reasoning questions), and reaction time (RT, a timed pairs matching exercise); both were considered continuous variables for modelling. We included the following CMR metrics: left and right ventricular (LV and RV) volumes in end-diastole and end-systole, LV/RV ejection fractions, LV/RV stroke volumes, LV mass, and aortic distensibility. Multivariable linear regression models were used to estimate the association of each CMR measure with FI and RT, adjusting for age, sex, smoking, education, deprivation, diabetes, hypertension, high cholesterol, prior myocardial infarction, alcohol intake, and exercise level. We report standardized beta-coefficients, 95% confidence intervals, and P-values adjusted for multiple testing. In this predominantly healthy cohort (average age 63.0 ± 7.5 years), better cognitive performance (higher FI, lower RT) was associated with larger LV/RV volumes, higher LV/RV stroke volumes, greater LV mass, and greater aortic distensibility in fully adjusted models. There was some evidence of non-linearity in the relationship between FI and LV end-systolic volume, with reversal of the direction of association at very high volumes. Associations were consistent for men and women and in different ages. Conclusion Better cognitive performance is associated with CMR measures likely representing a healthier cardiovascular phenotype. These relationships remained significant after adjustment for a range of cardiometabolic, lifestyle, and demographic factors, suggesting possible involvement of alternative disease mechanisms.

Funder

British Heart Foundation Clinical Research Training Fellowship

‘SmartHeart’ EPSRC programme

European Regional Development Fund and Barts Charity

UK Medical Research Council

NIHR Southampton Biomedical Research Centre, University of Southampton, and University Hospital Southampton

British Heart Foundation

Oxford NIHR Biomedical Research Centre and S.N. by the Oxford British Heart Foundation Centre of Research Excellence

NIHR Oxford Health Biomedical Research Centre and the Wellcome Centre for Integrative Neuroimaging

UK Alzheimer’s Society Research Fellowship

Publisher

Oxford University Press (OUP)