Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images-Reference-Cited by-同舟云学术

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

Published:2023-06-02 Issue:6648 Volume:380 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhao Bingxin¹²^ORCID,Li Tengfei³⁴^ORCID,Fan Zirui¹²,Yang Yue⁵^ORCID,Shu Juan²,Yang Xiaochen²,Wang Xifeng⁵^ORCID,Luo Tianyou⁵,Tang Jiarui⁵,Xiong Di⁵,Wu Zhenyi²^ORCID,Li Bingxuan⁶^ORCID,Chen Jie⁵,Shan Yue⁵,Tomlinson Chalmer⁵^ORCID,Zhu Ziliang⁵,Li Yun⁵⁷^ORCID,Stein Jason L.⁷⁸^ORCID,Zhu Hongtu⁴⁵⁷⁹¹⁰^ORCID

Affiliation:

1. Department of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Statistics, Purdue University, West Lafayette, IN 47907, USA.

3. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

4. Biomedical Research Imaging Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

5. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

6. Department of Computer Science, Purdue University, West Lafayette, IN 47907, USA.

7. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

8. UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

9. Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

10. Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is known about the phenotypic and genetic links of heart-brain systems. We quantified heart-brain connections using multiorgan magnetic resonance imaging (MRI) data from more than 40,000 subjects. Heart MRI traits displayed numerous association patterns with brain gray matter morphometry, white matter microstructure, and functional networks. We identified 80 associated genomic loci ( P < 6.09 × 10 −10 ) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.abn6598

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