DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport

Author:

Hartill Verity L1,van de Hoek Glenn23,Patel Mitali P45,Little Rosie6,Watson Christopher M7,Berry Ian R7,Shoemark Amelia89,Abdelmottaleb Dina110,Parkes Emma11,Bacchelli Chiara45,Szymanska Katarzyna1,Knoers Nine V3,Scambler Peter J512,Ueffing Marius13,Boldt Karsten13,Yates Robert514,Winyard Paul J12,Adler Beryl15,Moya Eduardo16,Hattingh Louise16,Shenoy Anil16,Hogg Claire8,Sheridan Eamonn1,Roepman Ronald17,Norris Dominic6,Mitchison Hannah M45,Giles Rachel H2,Johnson Colin A1ORCID

Affiliation:

1. Leeds Institute of Biomedical and Clinical Sciences, Faculty of Medicine & Health, University of Leeds, Leeds LS9 7TF, UK

2. Department of Nephrology and Hypertension

3. Department of Medical Genetics, University Medical Center, Utrecht, 3508 GA, The Netherlands

4. Genetics and Genomic Medicine Programme, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK

5. NIHR Great Ormond Street Hospital Biomedical Research Centre, London WC1N 1EH, UK

6. Mammalian Genetics Unit, MRC Harwell Institute, Harwell Campus, Oxfordshire OX11 0RD, UK

7. Leeds Genetics Laboratory, Leeds Teaching Hospitals NHS Trust, Leeds LS9 7TF, UK

8. PCD Diagnostic Team and Department of Paediatric Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London SW3 6NP, UK

9. School of Medicine, University of Dundee, Dundee DD1 9SY, UK

10. Department of Zoology, Faculty of Science, Benha University, Benha, Egypt

11. Manchester Royal Infirmary, Manchester M13 9WL, UK

12. Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK

13. Department for Ophthalmology, Institute for Ophthalmic Research and Medical Bioanalytics Core, University of Tübingen, 72074 Tübingen, Germany

14. Paediatric Cardiology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London WC1N 3JH, UK

15. Department of Paediatrics, Luton and Dunstable Hospital NHS Trust, Luton LU4 0DZ, UK

16. Department of Paediatrics, Bradford Teaching Hospitals NHS Trust, Bradford BD9 6RJ, UK

17. Department of Human Genetics, Radboud University Medical Center, 6500HB Nijmegen, The Netherlands

Funder

NIH

British Heart Foundation

Medical Research Council

Action Medical Research

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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