Plasma Cell–Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients-Reference-Cited by-同舟云学术

Plasma Cell–Free DNA Next-Generation Sequencing to Diagnose and Monitor Infections in Allogeneic Hematopoietic Stem Cell Transplant Patients

Published:2018-11-16 Issue:12 Volume:5 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Fung Monica¹,Zompi Simona²,Seng Hon²,Hollemon Desiree²,Parham Adama²,Hong David K²,Bercovici Sivan²,Dolan Estelle³,Lien Kathy¹,Teraoka Justin¹,Logan Aaron C⁴,Chin-Hong Peter¹

Affiliation:

1. Division of Infectious Diseases, University of California San Francisco, San Francisco, California

2. Karius, Inc., Redwood City, California

3. School of Medicine, University of California Davis, Sacramento, California

4. Division of Hematology and Blood and Marrow Transplantation, University of California San Francisco, San Francisco, California

Abstract

Abstract Allogeneic hematopoietic stem cell transplant patients are at risk for common and atypical infections. Superior diagnostics can decrease infection-related morbidity and mortality. A novel plasma cell–free DNA next-generation sequencing test detected an uncommon presentation of Chlamydia trachomatis and recurrent and metastatic complications of Staphylococcus aureus bacteremia before standard microbiology.

Funder

Karius, Inc.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/5/12/ofy301/33576957/ofy301.pdf

Reference15 articles.

1. Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology;Wingard;Infect Dis Clin North Am,2010

2. Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases;Simner;Clin Infect Dis,2018

3. Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease;Blauwkamp;Nat Microbiol