Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing-Reference-Cited by-同舟云学术

Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing

Published:2016 Issue:3 Volume:3 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Abril Maria K.¹,Barnett Adam S.¹,Wegermann Kara¹,Fountain Eric¹,Strand Andrew²,Heyman Benjamin M.³,Blough Britton A.⁴,Swaminathan Aparna C.⁴,Sharma-Kuinkel Batu²,Ruffin Felicia²,Alexander Barbara D.²,McCall Chad M.⁵,Costa Sylvia F.²,Arcasoy Murat O.³,Hong David K.⁶,Blauwkamp Timothy A.⁶,Kertesz Michael⁶,Fowler Vance G.²,Kraft Bryan D.⁴

Affiliation:

1. Department of Medicine

2. Divisions of Infectious Diseases

3. Hematology

4. Pulmonary, Allergy, and Critical Care Medicine

5. Department of Pathology, Duke University Medical Center, Durham, North Carolina

6. Karius, Inc., Menlo Park, California

Abstract

Abstract We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/3/3/ofw144/33622159/ofw144.pdf

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3. Sepsis in European intensive care units: results of the SOAP study;Vincent;Crit Care Med,2006